Cerebral hemodynamic and metabolic changes in fulminant hepatic failure

Cerebral hemodynamic and metabolic changes in fulminant hepatic failure: a retrospective study.

The purpose of this retrospective study was to determine cerebral hemodynamic and metabolic changes in comatose patients with fulminant hepatic failure. Computerized tomography of the brain and cerebral blood flow measurements by the xenon-computerized tomography scan or intravenous xenon-133 methods were obtained in 33 patients with fulminant hepatic failure. In a subgroup of 22 patients, arte...

Glyphosate Poisoning with Acute Fulminant Hepatic Failure

Background: Glyphosate containing herbicides are widely used the world over. They are marketed as nontoxic to humans, but numerous studies have showed that these glyphosate-based herbicides (GlySH) can cause multiorgan damage.1 Recent reports of animal studies on rats have raised a doubt of liver damage after long term exposure to GlySH. Case Presentation: a young male had chronic exposure to G...

Acid-base and metabolic disturbances in fulminant hepatic failure.

In 28 patients with fulminant hepatic failure alkalaemia was present in 49 of a total of 65 observations. Alkalaemia was due primarlily to a low Pa, C02 in 30 instances and to raised plasma bicarbonate in 16 instances. Blood lactate, pyruvate, and acetoacetate were significantly raised, and in individual cases, blood citrate, succinate, and fumarate were elevated. Blood citrate rose progressive...

Pathophysiology of cerebral edema in fulminant hepatic failure.

F hepatic failure (FHF) is a devastating disease and is still associated with a high mortality (1). FHF results in progressive multi-organ failure with a dramatic impact on the brain. Indeed, development of intracranial hypertension (IH) is a leading cause of death in FHF. During this decade two theories have independently emerged to explain the pathogenesis of cerebral edema and intrac...

Fulminant hepatic failure due to metastatic choroidal melanoma